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why cone formation during dissolution?
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we run the same sample in same method in different flow rates in HPLC,any changes in sample analysis?
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In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.
How to select buffer for HPLC mobile phase
4 Answers Cadila, Cipla, Lupin,
Organic Chemistry 
