b.gangatharan


{ City } tiruchy
< Country > india
* Profession * sr.executive
User No # 123577
Total Questions Posted # 16
Total Answers Posted # 42

Total Answers Posted for My Questions # 17
Total Views for My Questions # 48637

Users Marked my Answers as Correct # 166
Users Marked my Answers as Wrong # 8
Questions / { b.gangatharan }
Questions Answers Category Views Company eMail

What is UV cut off?

Sanmar,

1 Analytical Chemistry 2684

What is impurities in pharma analysis?

 1 Analytical Chemistry 1882

What are the different zones in stability according to ICH?

Apotex,

1 Analytical Chemistry 2140

According to ICH,India is coming under which climatic zones?

Cipla,

1 Analytical Chemistry 2404

How does GC did work?

 1 Analytical Chemistry 1787

Which detector is used in uv-vis spectrophotometer?

Glenmark,

1 Analytical Chemistry 9103

Why chromic acid wash is not recommended by USP for glassware cleaning?

Lupin,

1 Analytical Chemistry 1805

What is the difference between ROI & sulphates ash?

 1 Analytical Chemistry 2492

What is difference between NDA & ANDA ?

Alembic,

1 Analytical Chemistry 3319

What is Rf value& Rx value in TLC?

Abbott,

1 Analytical Chemistry 8028

What is the difference between drug product and drug substance?

Apotex,

1 Analytical Chemistry 2318

What is excipient in drug product?

Lupin,

1 Analytical Chemistry 1811

What is GF254 means in TLC plate?

Abbott,

1 Analytical Chemistry 2359

What is zero water in TOC Analysis?

Orchid,

1 Analytical Chemistry 1921

What are the class-1 residual solvents listed in ICH guidelines?

 2 Analytical Chemistry 2752

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Answers / { b.gangatharan }

Question { 13077 }

What is the difference between low pressure gredient and high
pressure gredient in hplc instrument?


Answer

In simple definition,we can say that in low pressure gradient sample mixing with mobile phase will take place before pump and in high pressure gradient it will take place after pump.
Thanks,
B.Gangatharan,
Caplin point Ltd-unit-1
Pondicherry.

Is This Answer Correct ?    2 Yes 0 No

Question { Sanmar, 7063 }

What is the Difference between Humidity and Relative Humidity ?


Answer

Humidity is amount of water vapor in atmosphere.Relative humidity is measurement of current humidity in relation to given temperature.for example if RH is 50% means air is partially saturated with water vapor.
Thanks,
B.Gangatharan,
Caplin point.

Is This Answer Correct ?    0 Yes 0 No


Question { Kilitch, 25393 }

why we use only sucrose in the calibration of polarimeter?


Answer

Sucrose does not have mutarotation.so sucrose is used for polarimeter calibration.we can not use glucose&Fructose because they are having mutarotation.change in optical rotation is called mutarotation.
Thanks,
B.Gangatharan,
Caplin point laboratory,
Puducherry.

Is This Answer Correct ?    2 Yes 0 No

Question { Dr Reddys, 2705 }

What is the pilot-plant in pharma sector.


Answer

Small scale Trials are generally taken in pilot plants before going for large scale production .
Thanks,
B.Gangatharan,
Caplin point,
Puducherry.

Is This Answer Correct ?    2 Yes 0 No

Question { 9323 }

How to calculate signal to noise ratio by this formula 2H/h
where h from where and how to measure


Answer

S/N =2H/h where ,H is height of main peak and h is height of noise in the range x5 from main peak.
Regards,
Gangatharan.B
Caplin point.

Is This Answer Correct ?    1 Yes 0 No

Question { Matrix, 22532 }

Why do we use sodium salicylate for Calibration TLC Cabinet
U.V Lamps


Answer

Sodium salicylate has 4 double bonds in its structure.due to this conjugated double bond structure it shows clear spot in shorter wavelength(254nm)and longer wavelength(365nm) during UV cabinet calibration for TLC.
Thanks,
B.Gangatharan,
Caplin Point,
Puducherry.

Is This Answer Correct ?    6 Yes 0 No

Question { Lee Pharma, 7852 }

why we use sodium salicylate in uv light calibration at TLC
chamber


Answer

Sodium salicylate has 4 double bonds in its structure.due to this conjugated double bond system,it shows clear spot at shorter wavelength(254nm)and longer wavelength(365nm) in UV cabinet calibration for TLC.
Thanks,
B.Gangatharan.
Caplin point,
Puducherry.

Is This Answer Correct ?    2 Yes 0 No

Question { Raks Pharma, 8707 }

what is difference between IR lamp and polarimeter lamp


Answer

IR lamp is called as GLOBAR and it will produce only IR rays.but in polarimeter two different lamps are used.one is sodium lamp and it will produce D-LINE Rays at 589nm and another one is mercury lamp and it will produce mercury line rays at 546nm.
Thanks,
B.Gangatharan,
Caplin point labs,
Puducherry.

Is This Answer Correct ?    1 Yes 0 No

Question { Biocon, 4676 }

Sulphated Ash incresed it will effect on product yield?


Answer

No.If the sulphated Ash is high means,inorganic materials are found high and it is danger for our health.
It will not affect the product yield because it is present in material in 0.1 percentage only.
Thanks,
B.gangatharan.
Caplin point .

Is This Answer Correct ?    0 Yes 0 No

Question { Biocon, 4676 }

Sulphated Ash incresed it will effect on product yield?


Answer

It will not affect product yield because according to USP acceptable level in product is NMT 10ppm(0.001%)only.
Thanks,
B.Gangatharan

Is This Answer Correct ?    0 Yes 0 No

Question { Wockhardt, 11548 }

What are the different types of columns used in HPLC


Answer

1.Normal phase columns
2.Reverse phase columns
3.Ion Exchange columns
4.Size Exclusion columns
Thanks,
B.gangatharan,
Caplin point,
Puducherry.

Is This Answer Correct ?    2 Yes 0 No

Question { Police Constable, 2377 }

wat is the role of michelson interferometer in FTIR and He-Ne lase.detailed answer required in simple language


Answer

Michelson interferometer is used for very fast scanning from 4000 to 400 cm-1 within seconds in pharma industry.without Michelson interferometer it will take long hours for scanning.
Thanks,
B.gangatharan,
Caplin point,
Puducherry.

Is This Answer Correct ?    2 Yes 0 No

Question { Divis Laboratories, 14839 }

gc Calibration % RSD failed what is the possible reasons?


Answer

If %RSD is failing in GC calibration means we have to check & replace following things,
1.Injector septa
2.glass wools in liner
3.syringe
Thanks,
B.Gangatharan.

Is This Answer Correct ?    4 Yes 0 No

Question { Amoli Organics, 5435 }

Why water not directed by FID detector 


Answer

FID in GC does not detect water because it will not burn.but we can go for TCD for detect water molecules in sample.
Thanks,
B.Gangatharan,
Caplin point lab.

Is This Answer Correct ?    1 Yes 0 No

Question { Sun Pharma, 2740 }

What is the meaning of Base deactivated vials


Answer

Base deactivated vials have silanized surface to prevent adsorption of highly polar molecules.
Thanks,
B.Gangatharan,
Caplin point,
Puducherry.

Is This Answer Correct ?    2 Yes 0 No

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