Answer / ashish patel

To control and monitor isomeric impurity (only toxic) 

Answer / rajasekhar

Some samples have chiral centers . These samples cant saparate reverse phase columns and Narmal phase columns. We can saparate these sample only Chiral columns.Due to charal samples have Isomers, these isomers have same polarity and phisical property.
In chiral columns have one Isomer , which interacts with sample isomers differently , thats why we can saparate.

Answer / babu1029

Also we know the percentage of ee

Answer / tejas

attached functional group are different. then it is called chiral. it can be done on GC also or it can be done by reverse phase column also by using pre column derivatization compound.

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