Answer / rajendra gaikawad

I think , our body constitute various chemical compounds i.e HCL , Phosphate buffer,acetate buffer.
Hence when we make any new product,whether that product release the drug in these different medium or not.
Since sometimes the site of action is different and whether our drug will release the drug in other medium or not.
Hence to ckeck drug release other than stomach multimedia dissolution profiling is done.

Answer / sandeep singh

If the dissolution is slower
than gastric emptying, a dissolution profile with multiple time points in multimedia is
recommended.
In the case of low solubility/high permeability drugs (case 2), drug dissolution may be the rate
limiting step for drug absorption and an IVIVC may be expected. A dissolution profile in multiple
media is recommended for drug products in this category.

Answer / manas

since body consist of different mediums,we perfom disso test in different media to make sure which media is suitable for a specific entity(drug) to give a maximum dissolution disso graph/value.
Taking into acccount of a new drug formulation when we are not sure about the media to perform disso or not specified in OGD,so multi-media disso is recommended to make sure of the disso media for a drug.

Answer / rajaguru

Human is body constitute more chemicals that using multimedia
Water 0.1N Hcl,0.01N Hcl ,PH 4.5 acetate buffer PH 6.8 phosphate buffer this are the multimedia check drug releaseis different media or not

what is the difference b/w repeatability nd reproducibility ?

1 Answers   Aptuit Laurus,

---

What is difference between NDA & ANDA ?

1 Answers   Alembic,

---

What the difference in loss on drying and residue on ignition

2 Answers  

---

What is the difference between Optical rotation and Spcefic optical rotation

2 Answers   IPCA, Matrix,

---

in determination of(acetone) moister content we are using methanol replaced by pyredine.what hapend in that reaction.

2 Answers   Glenmark, Neuland,

---

As per USP u/vacuum means (how much vacuum should be applied)?

1 Answers   Mylan,

---

why are measure gas flow " ml " in Gas chromatography

0 Answers  

---

Why should we use Potassium iodide and Hydrochloric acid during preparation of Iodine Molar solution?

1 Answers  

---

give clarity of linearity and range in method validation

0 Answers  

---

why the sucrose used in calibration of polarimeter

5 Answers   Neuland,

---

why holium oxide prepared in 10% HCLO4 SOLUTION

0 Answers  

---

Whya the need of Specificity to do in Analytical Method Validation ?

5 Answers   Dr Reddys,

---