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in pentoperazole capsules usp why assay value is substract
from dissolution
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Answer / dnyaneshwar
In case of Pentaprazole Enteric coated Tablet,As per USP ( % Released at Acid stage = Assay - Content after acid stage ).
Solution : Petaprazole molecules is very unstable in 0.1 M HCl i.e highly degraded.At the time of acid stage dissolution,the release of pentaprazole will start to degrade very fastly.Release & degradation rate take place simultaneously.Thus to determine actual released at acid dissolution after 2 hrs we can determine by above formula
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