Answer Posted / rajendra gaikawad

I think , our body constitute various chemical compounds i.e HCL , Phosphate buffer,acetate buffer.
Hence when we make any new product,whether that product release the drug in these different medium or not.
Since sometimes the site of action is different and whether our drug will release the drug in other medium or not.
Hence to ckeck drug release other than stomach multimedia dissolution profiling is done.

How to set specification of assay, fisdolution and related substances?

866

---

effect of pore size, pore volume, partical size, column length, carbon load on retention time? what is carbon load? what is the use?

913

---

can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?

2175

---

What are modes of quantification in related substances

2161

---

What is the formula for relative diffrence for standard solution in solution stability in validation?

789

---

how we can identify the impurity is coming below loq at transfering site?

863

---

why we are using hexane in calibration of number of drop per mL

1728

---

why are measure gas flow " ml " in Gas chromatography

1650

---

how to set sample and standard concentration in RS method?

892

---

4. Describe the operation of the Craig apparatus. Chapter.3 Equilibrium Processes in Separations

2713

---

AT WHAT CONDITIONS WILL YOU ANALYSE A SAMPLE,WHICH ARE PRESERVED AT OTHER THAN THE AMBIENT CONDITIONS?(ie COLD STORAGE SAMPLES BELOW 20* CENTIGRADE?

2043

---

How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.

2301

---

how require to fix the linearity and accuracy cincentration range?

1660

---

From where require to take the RLD sample?

748

---

Please give idea about method development for cleaning method and how maco level establish

739

---