what is the difference of use of LOD test and Karl Fischer
titra.?
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Answer / vaishali
In LOD test both organic solvents and water content are
determined.
& in karl fisher titration only water content is determined.
| Is This Answer Correct ? | 66 Yes | 1 No |
Answer / vikky
In water by KF test we can determine water content only
whera as in LOD test we can determine % of volatile
Solvents and water in drug substance.
| Is This Answer Correct ? | 26 Yes | 4 No |
Answer / sudhakar.saidam
LOD:To determine find out the solvent presentage in drug
MC: TO determine find out the water percentage in drug
| Is This Answer Correct ? | 26 Yes | 6 No |
Answer / k.shiva
LOD: To determine find out the solvent presentage in drug
MC: TO determine find out the water percentage in drug
| Is This Answer Correct ? | 19 Yes | 5 No |
Answer / raminder singh
Water By KF is to determine Bound or in bound water which
is present in Drug molecule But in LOD determine organic
volatile impurities evapoated on drying the sample at
specified condition
| Is This Answer Correct ? | 17 Yes | 4 No |
Answer / ram.ch
In LOD test both organic solvents and water content are
determined.
& in karl fisher titration only water content is determined.
| Is This Answer Correct ? | 13 Yes | 3 No |
Answer / sudha
In water by KF test we can determine only water content
wher as in LOD test we can determine % of volatile
Solvents and water in drug substance based on nature of
melting range. If melting range is LESS than 105°c then
LOD COUNTS AS % of volatile Solvents only.
| Is This Answer Correct ? | 10 Yes | 1 No |
Answer / falguni
In LOD We can measure loss of Volatile solvent (depend on
their boiling point)and also loss of adsorbed water (upto
some extent). In karl fischer we can find total content of
water, whether it is adsorbed or absorbed.
| Is This Answer Correct ? | 2 Yes | 0 No |
Answer / s.goutham
from LOD we get mc aswlaa any solvent is present in the
sample .But kfr only giv mc content
| Is This Answer Correct ? | 2 Yes | 1 No |
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2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.
Organic Chemistry 
