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what is the difference of use of LOD test and Karl Fischer
titra.?
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Answer Posted / sudha
In water by KF test we can determine only water content
wher as in LOD test we can determine % of volatile
Solvents and water in drug substance based on nature of
melting range. If melting range is LESS than 105°c then
LOD COUNTS AS % of volatile Solvents only.
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