Answer / mr.bujji reddy kanchi

GC-HS is useful for Residual solvents. since the sample is
heated about 40 minutes. then the volatiles present in the
sample will come to the empty space(Head space)of the vial.
then the needle will suck the vapour and inject into GC. It
means we are extracting the volatiles from the material
before injection.

In case of GC- Direct injection, sample also will go into
GC.

Answer / vishnu dutt pandey,lupin limit

1.In GC Liquid Injection made.While in GC-HS vapours of
volatile solvents injected.
2.In GC we analysed only residual solvents of those
substances which is in liquid state.
3.Through GC-HS we analysed residual solvents of those
substances which is in Solid [api, Tablet] & liquid both
state state.Because when we crush the solid for made
solution in diluent for liquid injection there is some
temperature genarate, the low boiler is vaporised & we can't
get accurate result of the material.

Answer / ravi.a

gc and gc-hs both are used for residual solvents in by gc
we measured for volatile solvents in this direct inject the
sample into the column and in gc-hs is also used for
volatile sovents in this we apply the pressure to inject
the solvent as vapour into the column
and both r used for non volatile solvents there are
converted into voltile solvents

Answer / gaurav khurana

Gc and gchs both are used for residual solvent but difference between gc sample completely dissolve in base solvent(dmso, dmf,nmp) and clearly soluble. But gchs samples not necessary dissolve in base solvent but we check residual solvent in substance. Because gchs in headspace only vapour transfer in gc .Sample is not direct impact in injector port.But direct sample inject in injector port in gc .These is damage injector port of gc.

Answer / trinadh, vasudha pharma (r&

Useful for finding % purity and impurity profile of Petroleum Hydrocarbon, Flavours, Drugs, Pesticides and solvents. Analysis of gaseous sample. Detection of residual chlorinated compounds. Detection of trace level of solvents in drugs.Detection of volatile organic content in drugs, dyes, carbohydrates and polymers etc by GC-HS.

Answer / dvksarma

sample analyse at low conc level on gc-hs.

Answer / trinadha rao,vasudha pharma ch

Gc-it is analyzed liquid samples only
Gc-hs:-It is analyzed liquid and solid sample s also
It is done organic volatile impurities

Answer / dr. nalla kumar ponnuswamy

GC-HS is useful for Residual solvents. Since the sample is heated about 40 minutes. Then the volatiles present in the sample will come to the empty space (Head space) of the vial. Then the needle will suck the vapour and inject into GC. It means we are extracting the volatiles from the material before injection.

GC and GC-HS both are used for residual solvents in by GC we measured for volatile solvents in this direct inject the sample into the column and in GC-HS is also used for volatile solvents in this we apply the pressure to inject the solvent as vapour into the column and both r used for non-volatile solvents there are converted into volatile solvents.
Useful for finding % purity and impurity profile of Petroleum Hydrocarbon, Flavours, Drugs, Pesticides and solvents. Analysis of gaseous sample. Detection of residual chlorinated compounds. Detection of trace level of solvents in drugs. Detection of volatile organic content in drugs, dyes, carbohydrates and polymers etc. by GC-HS.

Answer / lingeswar konne

GC ALS AND GC HS Difference injection technique,
GC ALS Inject the liquid and small volume (like 0.2,0.5 or 10ul)
GC HS inject the vapour directly large volume (1ml)
ALS solid must be dissolve solvents but HS Use diluent water also.
ALS Inject solvent including product but HS Inject only vapour stage of solvent.

Answer / kuchela rao athota neuland lab

GC-IT IS ANALYSED LIQUID SAMPLES ONLY
GC-HS:-IT IS ANALYSED LIQUID AND SOLID SAMPLE S ALSO
IT IS DONE OVI(ORGANIC VOLATILE IMPURITIES)

What is the defination of Bulk density?

4 Answers   Dr Reddys,

why linerity not use in GC but use in HPLC ?

6 Answers  

why we use pyridine to determine moisture content of acetonel

2 Answers   Lee Pharma,

how calculate column dead volume in hplc ?

3 Answers   Torrent Pharma,

verification of wave number why you are use in IR calibration

2 Answers  

diference b/w packed &capilary columns

2 Answers  

why we use vanillin in melting range calibration

3 Answers  

How do we fix the sample concentaryion in hplc method development?

0 Answers  

why you are using benzoic acid for water content determination in TEA

2 Answers  

Retention time & Relative Retention time Definition & between difference? How to Calculate response factor(RF) & relative response factor(RRF)?

3 Answers   MSN Pharma, Titan,

What is the definition of RRF

2 Answers  

how can we decide the limit of cleaning validation? What is the criteria for it?

2 Answers   Glenmark,