Answer / mukesh patel

impurity can be calculated against impurity when impurity
availability is sufficient.and easily available for routine
analysis and there is huge difference in RF or RRF with
main analylte.impurity can be calculated against diluted
standard with applying RRF when peak get saturated in
sample solution.

Answer / sp goswami

We need calc of imp RRF against impurity std when our
impurity responses are improper with st. phase of that
column and also if imp. is available in sufficient quantity
for diluted std we can cal for quantified results and if
impurity is less in amount and response is also less ,so to
get a perfect calculated % impurity we quantify it with
help of diluted std.
Regards

if your product is soluble in 0.1n hcl and water then which you choose as media from these 2 media?

0 Answers  

---

What is dose dumping? why require to do?

0 Answers  

---

How they found 1mL of K.F reagent is equivalent to 5mg of water and if we change the composition of K.F reagent, is it can neutralize more amount of water?

0 Answers  

---

Which type of analysis we have to done uv spectroscopy

2 Answers  

---

Why using 0.5% acetone in methanol mobile phase for HPLC Gradient performance check.

2 Answers   DRL,

---

In IR spectra, generally a molecule vibrates without apply emr or ir light?

0 Answers  

---

What is Fourier Transform Spectrosopy?

5 Answers   Aurobindo, Hetero, Lupin,

---

what is dead time in hplc?

3 Answers   Orchid,

---

What are usp limits for total impurities,unknown impurity

1 Answers   Dr Reddys,

---

What is the difference between qualitative and quantitative analysis (hplc)

1 Answers  

---

What is the deference between Residual solvents and OVI

1 Answers   RA Chem Pharma,

---

How did you conclude that when stressing a compond, all degradation products have eluted in chromatogram?

7 Answers   Matrix,

---