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what is the difference between M.C and LOD
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Answer / aditya
Hi to all
By using M.C We can measure Moisture Present in our drug
By using LOD we can determine only Class-3 Solvents according ICH Q3C_R5 besides moisture content..
Only Class 3 solvents are likely to be present. Loss on drying is less than 0.5%.
If it is wrong please let me know right one
Than Q
| Is This Answer Correct ? | 2 Yes | 0 No |
by m.c. we have to found out only water content present in the sample
while lod we have to find out water content and any solvents{non volatile}present in the sample
| Is This Answer Correct ? | 1 Yes | 0 No |
mc :onely water content identificaton
lod:water & solvents identificaton
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / md. prince bpharm
Moisture content = Intramolecular water + Extramolecular water
Lose on drying = Extramolecular water + Non-volatile substance
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / g,kiran
BY m.c We can findout only water content in a drug
while LOD result gives water content solvent present in
substance. Thus, LOD content is always hIgher than M.C.
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / srinath
Moisture content how must water in present in the sample &
Lod how much water in that sample &non volatil solvents present that sample
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / ravi
what are the differences between empower-2 and empower-3 softawre
| Is This Answer Correct ? | 0 Yes | 0 No |
Answer / abdullah al mamun
Loss on drying measures all weight loss after heating to a specific temperature for a specific time. This value will include moisture as well as any volatile components or solvents that may be present.
Moisture content is only a measure of the water is present in sample
| Is This Answer Correct ? | 0 Yes | 0 No |
Answer / suresh babu
MC is used for only for determination of water content.
LOD is used for identification of organic volatile solvents.
| Is This Answer Correct ? | 5 Yes | 6 No |
Answer / prabahaker reddy
LOD --- THE SOLVENT PERCENTAGE IN THE PRODUCT.
MC --- THE WATER CONTENT IN THE PRODUCT.
| Is This Answer Correct ? | 6 Yes | 10 No |
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11 Answers Aurobindo, GVK, Sohan Healthcare,
Organic Chemistry 
