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Analytical Chemistry Interview Questions
Questions Answers Views Company eMail

What are the different types of columns used in HPLC

Wockhardt,

3 13266

In HPLC when we use Isocratic method, Gradient method in hplc?

Pharmaceutical,

8 22774

Any molecule is filing for ANDA purpose, what are the dissolution requirements / specifications needed ?

IPCA,

1 6436

What is Endcapped Hplc column

 2 9752

Why we more noise in PDA detector compared to UV detector?

Aurobindo,

1 11758

if the purity is 99.9%,is need to do assay?

Reddy Labs,

3 15250

What is the difference between specified impurity and Identified impurity

Glenmark,

3 16387

What is the difference between specified impurity and Identified impurity

Merchant Navy,

1 6164

how do you established the RRF for unknown impurity

Square Pharma,

6 13382

I want analyze my compound at 325 nm so which standard shall i use to calibrate my HPLC system? How i can assure my hplc detector is suitable or not?

AMRI,

3 10279

How we will choose pH of a mobile phase if analyte pKa value is 4

Celon Labs, Laurus,

2 11496

what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?

DRL, Laurus,

3750

Which column is more polar, C8 or C18?

Cipla, Glenmark, Laurus, Torrent Power,

6 30636

what is the difference between heavy metals and sulphated ash

Aurobindo,

2 18241

what is difirence b/w ROI&ROE

Pfizer,

1 9767

Post New Analytical Chemistry Questions

Un-Answered Questions { Analytical Chemistry }

what is mean by ambient temperature?

983

inhouse product is in capsule form in combination and RLD is in tablet form then can we proceed for multimedia CDP? in inhouse capsule product disso is paddle with sinker in release media is there then RLD product in tablet form then with same as paddle with sinker we can proceed n.a.?

775

WHAT IS THE CRITERIA FOR SELECTION OF TIME OF DISSOLUTION AND THE MEDIUM OF DISSOLUTION?

2626

how you establish the LOQ?

844

If vendor having more imp than monograph then how to proceed? and how to set spec?

1005

What is the principle of HPLC, GC, LCMS, GCMS,LC QQQ, GC QQQ, LC Q TOF and GC Q TOF. What are the applications and Specificity?

8919

Why we used in n-butyl acetate water content terminology while in ethyl acetate we used moisture content terminology?

1906

How require to perform linearity as per ANVISA? What are the acceptance criteria?

1401

why require to add enzymes in capsules dissolution only? is it require to tablet also?

727

How to set analyticl specification for combination products?

799

If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

910

What is shaking level in GC?

835

How to determine the EDTA content by potentiometry titration in Ceftriaxine sodium

2616

why we are using hexane in calibration of number of drop per mL

1796

Why only Copper standard is used to calibrate Atomic Absorption spectrophotometer?

2787

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