Answer / rambabu cherukuri

Endcapping is a chemical procedure to reduce the polar nature of silica in RP HPLC coloumns by attaching the trimethyl silane to free silanol group

Answer / satish jannu

Endcapping:it is a chemical treatment with trimethyl silane
to romove excess silanol groups in hplc column to get more
polar stationary phase

Retention time & Relative Retention time Definition & between difference? How to Calculate response factor(RF) & relative response factor(RRF)?

3 Answers   MSN Pharma, Titan,

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we calibrate HPLC once in 6 months while iam doing calibration i came to know that calibration was failed. then how can i justify that the samples analyzed on the system during this 6 months was wright? how can i forward in to the next step for those batches?

5 Answers  

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in monograph 7 imp are there but in vendor showing 5 imp do not req to include 2 imp for that what will be justification?

0 Answers  

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what is batch no. of prednisole tablet.

8 Answers   Dr Reddys,

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how to regulate noise in HPLC?

2 Answers   Alkem Labs, Vimta Labs,

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What is the Deference between Bulk density & Tap density ?

2 Answers   Hikma Pharmaceuticals, Neuland, Reddy Labs,

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what is the defferance between the potency and working standard

1 Answers   Arbro Pharmaceuticals, Caplin Point, ECOlogics, Matrix, Orchid, Venus Remedies,

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Why the ph limit (1_14) Is used?

3 Answers   Cipla,

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what is regration method in method validation , how we can calculate it.

3 Answers   Cipla, Sun Pharma,

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why 1.2%kcl solution is using in limit os straylight?and why this test used for uv calibration?

1 Answers   Graviti Pharmaceuticals, Reddy Labs, Vimta Labs,

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if instrument calibration fails then what require to do?

0 Answers  

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why kf factor coming 0.5

5 Answers   Alkem Labs,

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