various methos to calculate precision in validation methods in HPLC?
Answers were Sorted based on User's Feedback
Answer / kumar
Precision will be expressed in two parts 1) system precision or repeatability -we can determine %rsd of same preparation with replicate injections 2)method precision or reproducibility or ruggedness or intermediate precision-we can determine %rsd of impurity content in replicate preparations and same experiment will be determine in different analysts,different instruments etc...
Is This Answer Correct ? | 3 Yes | 0 No |
Answer / santosh k sahoo
3 ways.
1. Repeatability: 3 concentration (n=3) or one concentration i.e.100% (n=6).
2. Intermediate Precision: samples to be run by either different analyst or different instrument or different days.
3. Reproducibility: samples to be run in 2 different labs.
In cases where reproducibility has been performed, intermediate precision is not needed
Is This Answer Correct ? | 1 Yes | 0 No |
if instrument calibration fails then what require to do?
Near infrared Principle
why lactose has less charges when packed in steel containers when compared with packing of lactose in polyamide material?
What are the terms used during Melting Range Analysis ?
why deutiriated chloroform used in NMR for sample prepration. what reaction takes place.give reasons
Why dissolution test is not performed in all of the products
In which situation we require to analytical method validation of excipient?
In pharmaceuticals formulation OOS applicable in Raw Material(which is not manufacturing in the company. and purchase by approved vendor)).Why?
how can I make the copper get white bye any salt or acit?
why does the result variation in hplc and gc with same sample ?
What are the primary standards?
if partition coefficient value was positive means, what it indicates ?