various methos to calculate precision in validation methods in HPLC?
Answer Posted / santosh k sahoo
3 ways.
1. Repeatability: 3 concentration (n=3) or one concentration i.e.100% (n=6).
2. Intermediate Precision: samples to be run by either different analyst or different instrument or different days.
3. Reproducibility: samples to be run in 2 different labs.
In cases where reproducibility has been performed, intermediate precision is not needed
| Is This Answer Correct ? | 1 Yes | 0 No |
Post New Answer View All Answers
why we use a particular hplc column for a particular compound give reasons?please
How do we fix the sample concentaryion in hplc method development. What is the basis?
Many times I don't got a caffeine peak in calibration of hplc using guard column ❓
What is the use of tlc and hplc? And when and where use?
from where i get mortar pastle for glass bottle crush? it's required for testing of it?
analytical method validation require to with respect to release specification or shelf life specification?
Hi sir if any product monograph not given known impurities (may be 5 impurities) specifications then how we require to proceed for inhouse formulation?
I have compare C2H2-air and C2H2-N2O flame AAS on determination calcium. Both use same range of std to plot calibration curve. (2-6ppm) When i measure the sample with phosphate, KCl and LaCl, C2H2-N2O flame give false positive result, around 0.5ppm. When i measure the sample with phosphste, KCl and EDTA. C2H2-N2O flame also give 0.5ppm false positive. But both above mentioned sample would not give false positive when measured by C2H2-air flame. What is the reason?
What is related substance by HPLC impurity limits as per USP?
1)What's the meaning of Absorption,give a example. 2)What's the meaning of Adsorption,give a example. 2)what is the difference between Absorption and Adsorption.
why are measure gas flow " ml " in Gas chromatography
if you have given one product then how you determine the impurity in that?
how to get accurate result for Residue on evaporation in purified water
why we use glass fiber filters use in some situation?
in which situation ion pair agent require to use?