Interested to Buy Any Domain ? << Click Here >> for more details...
I got 88.0 % assay for a drug in HPLC analysis for same
injection i got 40.0% related substances is it possible?
what is the relation between results of assay and purity?
- 5 Answers
- 12093 Views
- I also Faced
- E-Mail Answers
Answers were Sorted based on User's Feedback
Answer / muralikrishna ch
Practically the above case is not possible. I understood
related substances as impurities. If your sample is having
40% related substances your sample probably having assay
less than 60%.
| Is This Answer Correct ? | 14 Yes | 1 No |
PURITY IS QUALITATIVE ANALASIS
BUT ASAAY IS QUANTITATIVE ANALASIS.
EXP:-
CIPROFLOXACINE EXP
THIS PRODUCT PURITY IS 99.5% BUT ASSAY IS 99.8%
THE SAME PRODUCT PURITY IS 99.5% BUT ASSAY IS 80.0%
THE SAME PRODUCT PURITY IS 99.5% BUT ASSAY IS 50.0%
BECOUSE PURITY IS NOT DEPEND UP ON THE ASSAY.
| Is This Answer Correct ? | 11 Yes | 1 No |
Answer / s chatterjee
in Gabapentin, Imp A has a RRF of 12.6 i.e. against gabapentin standard. Say Gabapentin has degraded 12 % i.e. 88 % assay ( quantitative only) . When rel subs was calculated the Imp A against the gabapentin standard will give an quantitative value of 36 %. however, in reality as the correction factor is 12.6 then this comes to 36/12 = 3 % in reality.
Therefore it is important to know that the correction factor of related substances had been established against the drug used for quantification. Response of degradation products varies significantly from the drug candidate under UV.
| Is This Answer Correct ? | 2 Yes | 0 No |
Answer / falguni patel
Ya that may be possible. In purity, we compare area of our
main component with respect to impurities, while in assay
we compare it with standard. So in purity % of area will
devide with impurities.
| Is This Answer Correct ? | 2 Yes | 3 No |
Answer / a.prabhakar
May it is possible above case. Related substances is qualitative test but purity/assay is quantitative test.In quantitative test sample area compare with standard area.
| Is This Answer Correct ? | 1 Yes | 3 No |
how can you determine a compound acidic or basic?
How to define samples weight in moisture content
sop of a uv visible spectrophotometer double beam elico model
Why six unit used for precision?
How to determine water content of bis tetrazole amine mono ammonium salt
difference between calibration and validation
Tell me about analytical method validation in QC
we can use expired sample for validation and analyst qualification?
What the difference in loss on drying and residue on ignition
effect of Ph during analytical run ?
1 Answers Lambda Therapeutic Research,
if you get peak in blank then what require to do?
in each media we require to use SLS? how to proceed?
Organic Chemistry 
