During Validation study, Recovery is passing at all levels
but Linearity is failing. Justify?



During Validation study, Recovery is passing at all levels but Linearity is failing. Justify?..

Answer / p.chandra sekhar reddy

First we have to prove method is linear by linearity parameter then only we have to go for recovery by accuracy parameter.
But as per ur question accuracy performed first after that linearity failed.
If recovery pass in all levels means definatly method should be linear.
But it happens only in higher levels above 10℅ level, some times in lower levels below 10℅ level impurities areas will be fluctuate .

Is This Answer Correct ?    2 Yes 0 No

Post New Answer

More Analytical Chemistry Interview Questions

How we will choose pH of a mobile phase if analyte pKa value is 4

2 Answers   Celon Labs, Laurus,


Why are using in Hi,zero air, Ni gass are used GC

5 Answers   Aurobindo, ELBS, Vimta Labs,


Why use in sodium salicylate in uv lamps calibration

1 Answers   Auctus Pharma, Reddy Labs,


What is the difference between c8 and c18 hplc column?

1 Answers  


In HPLC Calibration, On which basis RSD Limit of noise test is fixed (NMT 33.0 % )

0 Answers   Alembic,






stability study is going on up to 3years for famotidine-USP but the pharmacopeia is revised and tlc test is replaced with hplc test. At the 4th year frequency the product is failed in hplc test .how can i assain the expiry or retest date and can i stop or continue the programme?

2 Answers   Nakoda Chemicals,


wat is reverse phase in hplc

2 Answers  


What is NPOC method in TOC?

1 Answers   Zydus Cadila,


Retention time & Relative Retention time Definition & between difference? How to Calculate response factor(RF) & relative response factor(RRF)?

3 Answers   MSN Pharma, Titan,


Explain what is a base line?

1 Answers  


In Agilent HPLC calibration using Empower 3 Software, What is the criteria for GPV Baseline starting point? i.e., Either it can start from -0.00/+0.00 or any range is there like -0.05 to +0.05 or ......etc?

1 Answers   Apotex,


What is Threshold in hplc?

2 Answers   Hetero,


Categories
  • Organic Chemistry Interview Questions Organic Chemistry (342)
  • Inorganic Chemistry Interview Questions Inorganic Chemistry (123)
  • Analytical Chemistry Interview Questions Analytical Chemistry (1387)
  • Physical Chemistry Interview Questions Physical Chemistry (62)
  • General Chemistry Interview Questions General Chemistry (478)
  • Chemistry AllOther Interview Questions Chemistry AllOther (190)