During Validation study, Recovery is passing at all levels
but Linearity is failing. Justify?
- 1 Answers
- 4446 Views
- Mylan, Torrent Pharma, I also Faced
- E-Mail Answers
Answer Posted / p.chandra sekhar reddy
First we have to prove method is linear by linearity parameter then only we have to go for recovery by accuracy parameter.
But as per ur question accuracy performed first after that linearity failed.
If recovery pass in all levels means definatly method should be linear.
But it happens only in higher levels above 10℅ level, some times in lower levels below 10℅ level impurities areas will be fluctuate .
| Is This Answer Correct ? | 2 Yes | 0 No |
Post New Answer View All Answers
WHAT IS THE PURPOSE WE USE HCL, CHOPPER, BURNER, MONOCHROMATOR in AAS? PLEASE EXPLAIN BRIEFLY
In the isomers,enantiomers give the only physical properties present such that no chemical properties present.
how to decide for one product require water content or LOD?
calibrtion procedue of LC-MS
Why we used in n-butyl acetate water content terminology while in ethyl acetate we used moisture content terminology?
function of detecter in hplc ,gc and spectroscopy? function of carrier gas in gc?
If combination product how require to identify which imp is of which api?
how a particular wavelength can be different for a particular compund while analysing by uv and by HPLC.
what is mean by dissolution biowaiver study?
which are the sizes of capsules?
How will u perform degradation study in detectors other thann PDA in HPLC Methodology
Related substance method equivalency on control sample or spiked sample?
How would you decide dissolution medium for NCE compound of class I drug
What are usp limits for theoritical plats,resoution,tailing factor,peak to valley ratio
My question about gas chromatography sulfur chemiluminsecence detector. I test unknown sample gas by GC-SCD (calibrated ) and the result of *H2S is 279 PPM , *but when I test the same sample with the GC-TCD (calibrated ) the value of *H2S is 2500 PPM . I'd like to inform you that both GCs are calibrated and have very good operation conditions with stable parameters . the question is if the sample gas with higher H2S over detection limits of SCD detector (1000 ppm). why the result it 279 ppm Best regards
