How will decide to use HPLC OR GC for developing method for
unkown compund
Answers were Sorted based on User's Feedback
Answer / tushar
First check it is volatile or non volatile because HPLC is
for volatile or non volatile component and GC is for only
volatile component.After for HPLC check solubility of
component then v can use check UV , PDA , Refractive index
detecter.GC for FID,TCD,ECD detecter etc.
| Is This Answer Correct ? | 37 Yes | 1 No |
Answer / aruna k
First cheeck the volatile nature & thermal stability of
compound,if it is highly volatile, thermal stable go for
gc,if it is not(i.e,non volatile&thermally unstable) we can
prefer hplc.
| Is This Answer Correct ? | 8 Yes | 0 No |
Answer / viss u
first check the UV spectrum of the compound if spectrum is
available go for hplc, if not that is UV inactive so start
method with GC.
| Is This Answer Correct ? | 5 Yes | 3 No |
if compound is volatile analytical method will by GC.
and if compound nonvolatile means it decomposes on heating
for this will use hplc.
| Is This Answer Correct ? | 4 Yes | 6 No |
What is Diffidence between Normal Detector and PDA Detector?
acceptance criteria for lod & loq by standard deviation of response and slope??
How can the GC or HPLC method is selected to determine the impurity profile in drug product?
what is the difference between mcg and ppm?
what is end capping in hplc coulmn
2 Answers Lupin, Zydus Cadila,
in which situation ion pair agent require to use?
which procedure we follow if 6th month of accelerated sample fail?
tell me about aliphatic acid estimation by hplc which columns can we use
Why use in sodium salicylate in uv lamps calibration
1 Answers Auctus Pharma, Reddy Labs,
i want to know about headspace and interview question on headspace
1 Answers Srikem Laboratories,
What is zero water in TOC Analysis?
Data was integrated with RRT CONCEPT OR Overlay with SSTchrmatogram concept which is better?