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In pharmacopeal solibility parameter of a material, is et essential to test all paramete? If 70-75% parameter passes can we assess that the material is satisfactory or not?
1 5388Why triethylamine and o-phosphoric acid used while setting pH of mobile phase during HPLC Analysis?
6 33857why RID detector is used for selective materials like Mannitol, Hydroxyethyl Starch and Sorbitol?
5 12646For Dissolution test why we are Performing 6 Bowls why not more.any were mentioned or in what basis we are performing? --------Veerabhadrarao.M
2 12256In Number of Theoretical Plates (N) = 16 (tr/w)2. where tr: retention time, and W: peak width. My Question is here in formula what is 16.Can u explain briefly? ---Veerabhadrarao.M
3 19611A new drug substance found fail to meet specification for an unknown Impurity during stability study(Specific change),how would further proceed?
2 7442Post New Analytical Chemistry Questions
What is similarity factor?
I have compare C2H2-air and C2H2-N2O flame AAS on determination calcium. Both use same range of std to plot calibration curve. (2-6ppm) When i measure the sample with phosphate, KCl and LaCl, C2H2-N2O flame give false positive result, around 0.5ppm. When i measure the sample with phosphste, KCl and EDTA. C2H2-N2O flame also give 0.5ppm false positive. But both above mentioned sample would not give false positive when measured by C2H2-air flame. What is the reason?
in which situation require to use paddle and basket?
please explian me about area normalisation method,diluted standard method,impurity vs impurity and which one has to be selected in method development
How would you decide dissolution medium for NCE compound of class I drug
How can the GC or HPLC method is selected to determine the impurity profile in drug product?
How to determine water content of bis tetrazole amine mono ammonium salt
mode of absorption in alimentary canal?
In HPLC calibration, caffeine is used as primary standard for wave length calibration due to caffeine is having dual maxima at 273 & 205 nm and one minima at 245 nm. Any body can give reference of these details from any pharmacopeia (with chapter no.) or any other authentic guideline?
Explain the relations between number of carbon atoms in alkanes and retention time ?
1.What is the difference between method validation and method verification 2.Which guidelines proposed to method transfer
How doing qbd practically?
Which type of column should i use to check the purity of high molecular weight protein using HPLC reverse phase column chromatography? Hi everyone. I wanna to check the purity of high molecular weight protein (collagen) with MW of ~130 kDa using a HPLC. I know C18
What is similarity factor and its use in api strength?
