Answer / madan joshi

The use of six dosage units as the basic sample size in
dissolution is partially due to the configuration of the
dissolution test assembly with six positions. However, in
some statistical procedures such as the estimation of a
confidence interval for precision of a measurement, a
sample size of six represents the point of diminishing
returns where the decrease in the confidence interval from
5 units is significantly greater than the decrease from 6
to 7 units. Thus the added value of obtaining additional
measurements is significantly less once six measurements
have been acquired.

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