How to establish pKa for a new API molecule ?

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How to establish pKa for a new API molecule ?..

BY HPLC, UV, TITRIMETRIC METHODS

Is This Answer Correct ?

4 Yes

5 No

How to establish pKa for a new API molecule ?..

HPLC(By using pH Buffer solutions),uv(By using pH Buffer
solutions),Solubility(By using pH Buffer solutions)

Is This Answer Correct ?

1 Yes

2 No

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