In KF Standardisation Why We using Disodium Tartarate?

Answers were Sorted based on User's Feedback



In KF Standardisation Why We using Disodium Tartarate?..

Answer / vattikuti rambabu

DST very Barely dissolved in methanol (water very hardly released) due to this reason use DST for KF instrument standardization purpose and one more standard use water for KF standardization purpose,water is very miscible in methanol due to this reason both used for KF standardization .both type of materials (barely released and easily released water) suitable for use instrument.
primary standard it have only two water molecule and gives
very accurate results (all atmosphere stable) .
Dst molicular formula is C4H4Na2O6.2H2O.
This molicular weight is 230.06.
Water content of DST is 15.66.
Calculation:In DST two water molicules are there=2*18=36
=(36/230.06*100)

Is This Answer Correct ?    3 Yes 0 No

In KF Standardisation Why We using Disodium Tartarate?..

Answer / rajesh goud

Though there are many chemical reagents which can be used as a primary standard for the standardization of KF reagent, DST is most commonly preferred because it has only two water molecules (C4H4Na2O6.2H2O).This DST gives Constant/same result water content By LOD (or)by KF titrator., i.e..about 15.66% of H2O.

Is This Answer Correct ?    3 Yes 1 No

In KF Standardisation Why We using Disodium Tartarate?..

Answer / lukka gowri shankar

1.0 DST is not absorb any moisture from the atmosphere in the room temperature.
2.0 DST is primary standard.
3.0 DST Had known water molecule(2H2O) and had constant water content value 15.66%
4.0 DST is easily dissolved in methanol and not degraded in methanol.

Is This Answer Correct ?    3 Yes 1 No

In KF Standardisation Why We using Disodium Tartarate?..

Answer / ---

In DST there are two water molecues. Those two are very
stable.Eventhough we are drying upto 105c the molecule is
stable.when DST reacts with another substance these two
water molecules are stable.DST is soluble in methanol.

Is This Answer Correct ?    1 Yes 0 No

In KF Standardisation Why We using Disodium Tartarate?..

Answer / ravindra kumar

No buddy clearly defined and chemistry behind the DST ,if we are using water for the determinatio of factor then same result are coming for both DST and water, Can any body suggest why DST is used for factory determination if the water content is NMT 1.0%

Is This Answer Correct ?    0 Yes 0 No

In KF Standardisation Why We using Disodium Tartarate?..

Answer / rajesh jaiswal

We can also use distilled water instead of DST, but we can not take water weight, hence DST is used.

During analysis, Ist methanol will take and neutralize moisture in methanol with some amount of KF & after that add DST & the water availability should be 15.6%.

DST is more stable
Very soluble in methanol
Two mol of hydrate stable
stable at 105 c
we can take wt

Is This Answer Correct ?    0 Yes 1 No

Post New Answer

More Pharmacy Interview Questions

what is medical representative

4 Answers   Apex, Ranbaxy,


What is the difference between Blend uniformtiy and content uniformtiy ?

1 Answers  


HOW TO PERFORM SATURATION SOLUBILITY IN DISSOLUTION METHOD DEVELOPMENT?

0 Answers   Micro Labs,


whem will be the exam or interview for the post of Drug inspector is conducted in jammu and kashmir??? the form was filled on starting of 2013.

0 Answers  


How will you calculate telling in any HPLC peak?

1 Answers  






there are how many leak sensor in shimandzu hplc,agilent hplc,dionex hplc and water's hplc?

4 Answers  


What are closely monitor parameters in stability study?

2 Answers  


when will be the drug inspector notification will be anounced.what are the educational requirements...

0 Answers   Reddy Labs,


solubility of drug in penetration enhancers is affected to the transdermal penetration of any drug yes or not? increase penetration with solubility or not?

0 Answers   Zydus Cadila,


What is the procedure to prepare the placebo?

4 Answers  


how quantitative stability studies are done?

0 Answers  


What should be Step wise the sterlization procedure for Dry Powder injection facility (from Starting)?

0 Answers   Nectar Lifesciences,


Categories