Why we selecting 900 ml dissolution medium perticular drug
as per I.P, USP?
- 2 Answers
- 10654 Views
- Akums, Torrent Pharma, I also Faced
- E-Mail Answers
Answers were Sorted based on User's Feedback
Answer / chetan
Sink condition: maximum daily dose should dissolve in 250mL of Media (it is related to, we are taking dosage form with a glass of water).
If dose is soluble in 250mL of water then developer can select 3X volume i.e 750mL or above.
Gastric Capacity of normal human being is considered aprox 900 to 1000mL so that much volume is selected.
| Is This Answer Correct ? | 14 Yes | 0 No |
Answer / puttaraj
first we measured the sink condition of particular drug ie
1 y third volume of the saturation level of solution.. due
to that reason 900ml media volume fixed.
| Is This Answer Correct ? | 0 Yes | 3 No |
How to calculate the RRF value in HPLC analysis.
If calibration of 12 bowl dissolution apparatus does not meets single stage procedure, how can you precede calibration?
Alprazolam has the potential for misuse and addiction. How would you approach prescribing Alprazolam to a patient with a history of substance abuse?
What is the difference between Humidity and Relative Humidity?
how many types of deviations? describe
what is limit of FDS In Related Substances?
2 Answers Dr Reddys, Mylan, Reddy Labs,
what is stationary phase
what do you mean by MACO
What is the difference between temporary change control and deviation?
how quantitative stability studies are done?
How to select temperature of ODT in disintegration test
what do you mean by Q+5 in dissolution
Pharmacy 
