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Can independent origins be established for two families of transport systems having no sequence or motif similarities without three-dimensional structural data?
993Are all members of transporter families confined to a particular organelle or to the plasma membrane, or are some family members found throughout cellular compartments in eukaryotes?
992Did shuffling of protein constituents occur between systems for multicomponent transport systems such as the atp-binding-cassette or complex protein secretion systems?
1040Did integral membrane transport proteins arise as an independent protein class or from other types of proteins?
942Did bacteria, archaea, and eukaryotes exchange transporter genes appreciably during the past two billion years?
1083Post New Bio Informatics Questions
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Have the proteins of a family generally acquired distinctive properties within each of these three kingdoms for ancient families that arose before bacteria, archaea and eukaryotes diverged?
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Suppose the Blast search returned 100 hits. Of these, 17 were false positives and we knew that there were 165 sequences in the database which should have returned a hit with our sequence. How many false negatives were there, and what is the sensitivity and selectivity of Blast in this instance?
