Can independent origins be established for two families of transport systems having no sequence or motif similarities without three-dimensional structural data?
595Are all members of transporter families confined to a particular organelle or to the plasma membrane, or are some family members found throughout cellular compartments in eukaryotes?
594Did shuffling of protein constituents occur between systems for multicomponent transport systems such as the atp-binding-cassette or complex protein secretion systems?
653Did integral membrane transport proteins arise as an independent protein class or from other types of proteins?
547Did bacteria, archaea, and eukaryotes exchange transporter genes appreciably during the past two billion years?
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