IF THE COMPOUND PKA IS 5.3 WHY WE ARE ADJUSTING PH+/-2 OF
THE COMPOUNDS PKA. WHAT IS THE CONDITION
Answer Posted / ramya sarma
pKa=pH+log [un ionised]/[ionised]
at the half neutralisation point
un ionised concentration= ionised concentration
so pKa=pH+log1
pKa=pH because log1=0
if we didnt adjudt pH +/-2.0 we may get peak split because
for un ionised we get one peak and ionised we get one more
peak
Is This Answer Correct ? | 3 Yes | 1 No |
Post New Answer View All Answers
Why dissolution test is not performed in all of the products
on saturation solubility study data how we can find out the bcs class of drug?
in OSD forms require to use gas chromatography?
How would you decide dissolution medium for NCE compound of class I drug
WHAT IS THE CRITERIA FOR SELECTION OF TIME OF DISSOLUTION AND THE MEDIUM OF DISSOLUTION?
why does used dry caffien in HPLC calibration?
what is the extinction coefficient for Indomethacin or at 319nm wave length.
what is difference in ods I ods II is this is realy from sorbent / packing characteristics or from other means
why require to add enzymes in capsules dissolution only? is it require to tablet also?
What is the calibration of uv process and preparation
we can use expired sample for validation and analyst qualification?
what is classification of elemental impurities? what is risk assement in elemental impurities?
If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?
we are performed SOR for a particular product the limit is -6 to -10.We face particular bathes it is not meeting the specification.we performed diffrent instrument diffrent analyst we are getting diffrent diffrent results.solvent is dimethyl sulfoxide what could be the reasion
WHY given much noise PDA dector then VWD Dector