Interested to Buy Any Domain ? << Click Here >> for more details...
why
we
have
to
use
only
900
ml
buffer
in
dissolution
apparatus ?
what
are
the
conditions
that
favours
the
selection
of
volume
of
buffer?
- 1 Answers
- 7183 Views
- I also Faced
- E-Mail Answers
Answer / t reddy
selecting volume of buffer depends upon the sink condition of the drug...
example: if ur drug maximum doasge is 500mg means.. take 3times of these dosage that is 1500mg... dissolve it 500ml buffer, there should not be any formation of precipitation in buffer... if there is any prcptn means increase the buffer volume until the drug getting completely dissolved... that will be the final volume for ur dissolution studies.
there is also another way 1st know the maximum solubility of dosage
example:if 500mg(consider this as 100%) in 900ml of buffer is the maximum solubility of the drug... then your doasge should not be more than 350mg(70%) in 900ml of buffer. u can use any dosage form less than 350mg for 900ml of buffer
| Is This Answer Correct ? | 6 Yes | 0 No |
How do you fix the known and unknown impurity limit for a drug substance?
why an employee go for medical representative instead of quality?
human body absorbs maximum amount of nutrients in
What is forced degradation study?
concomitant administration of 6-mercaptopurine and which product results in severe bonemarrow suppression?
What is the differance Between Calibration & Validation
6 Answers Gland Chemicals, MSN Pharma,
What is the role of buffers (ex: KH2PO4) in HPLC analysis,
what is immunity?
5 Answers GSK GlaxoSmithKline,
please e-mail me the model of Tamil Nadu drug inspector question papers
what are the best emulsifying agents used in o/w emulsion
how many deviation allowed
How to preform dissolution profiling
Pharmacy 
