Interested to Buy Any Domain ? << Click Here >> for more details...
why
we
have
to
use
only
900
ml
buffer
in
dissolution
apparatus ?
what
are
the
conditions
that
favours
the
selection
of
volume
of
buffer?
- 1 Answers
- 7101 Views
- I also Faced
- E-Mail Answers
Answer Posted / t reddy
selecting volume of buffer depends upon the sink condition of the drug...
example: if ur drug maximum doasge is 500mg means.. take 3times of these dosage that is 1500mg... dissolve it 500ml buffer, there should not be any formation of precipitation in buffer... if there is any prcptn means increase the buffer volume until the drug getting completely dissolved... that will be the final volume for ur dissolution studies.
there is also another way 1st know the maximum solubility of dosage
example:if 500mg(consider this as 100%) in 900ml of buffer is the maximum solubility of the drug... then your doasge should not be more than 350mg(70%) in 900ml of buffer. u can use any dosage form less than 350mg for 900ml of buffer
| Is This Answer Correct ? | 6 Yes | 0 No |
Post New Answer View All Answers
What is the basic requirement for preparing drug master file , like EDMF , USDMF ?
plz.mail me model papers of drug inspector of chhattisgarh..or MP.if Posible. Mail Id-recha_1428@rediffmail.com...mrs_1428@rediffmail.com,
when i come in contact with any metal items or clothes of fur i find myself shock and when run my fingers on fur clothes or matters, i find sparks. Is there any vitiams deffecieny in my body. If so, what i have to do?
How to preform dissolution profiling
what is ur strengths and weekness in ur professional life as medical rep?
how many clauses are there in iso? give me the clauses details?
please explain the job responsibilities of quality assurance..
What do you mean by GTT? What are the effect of GTT on film coating.
Can any one tell me that which brand hplc column is used for levetiracetam imp- b test.
Iam a B.PHARMA GRADUATE from DELHI UNIVERSITY and I am looking forward for DRUG INSPECTOR EXAM..kindly mail me any ques papaers reg the same...
how to calculate potency of working standard by using mass balence method & this calculated potency is on as basis or on anhydrous/ dried basis
what is the mechanism of action of local anaesthetics?
What is forced degradation study?
Hi Sir?Mam, If i complete SAS CLINICAL in India, can i step forward to USA for job trials? How far is it possible? Am a B.pharm student ,willing to make up my Master's degree too,will this both M.Pharm and SAS help me out to get a job in USA? Please help me out with a good answer.
How to do IR test of hydroscopic materials
