Answer Posted / pramod br

Relative Response Factor (RRF) is an analytical parameter used in chromatographic procedures to control impurities/degradants in drug substance and drug product.
RRF is used to correct the difference in detector response of impurities with analyte peak. RRF is established by the slope method with linear range of solutions (usually +/-50% of the specification level).
RRF= Slope of impurity / Slope of analyte.

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