Answer Posted / rishabh

First of all check your compound solubility in which solvents then after that based on solubility the Mphase selection becomes easy if compound is soluble in aqueous medium check the pH of that medium than after further procced if not then check the solubility in organic solvents on basis of solubility and pH of the Mobile phase. Both Mobile phase selection and stationary phase are selected.

How to set analytical specification for combination products?

774

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why we use a particular hplc column for a particular compound give reasons?please

2684

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We use hicrome 10 cxs column in hplc analysis....pls tell me.. what is the meaning of 10 cxs?

1673

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How to decide assay range for non pharmacopeial API analysis by HPLC? Could you give me any reference for same e.g Guidelines or Paper publications?

3303

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In which situation we require to prepare the standard solution from sample in Related substance method?

711

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Why a1% value is used for some product ? What is the criteria for selection a1% value ?

2289

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How can we calculate offset value pH measurment

1463

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what is the origin to prepare standard operating procedure

2248

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if your impurity coeluting with each other in that situation how require to set specification? is it acceptable?

900

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[3/30, 13:29] Manoj P Venkatpurwar: How hplc column selection according to structure? How mobile phase buffer selection on molecule structure?

709

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why cone formation during dissolution?

730

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how to qualify the impurity?

785

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Why we check moisture,ash & AIA in product

1821

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What is the accrptance criteria in RSD for RS method precision on basis of impurity percentages?

767

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What is the difference between spectro meter and spectro photo meter?

11345

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