Answer Posted / rishabh

First of all check your compound solubility in which solvents then after that based on solubility the Mphase selection becomes easy if compound is soluble in aqueous medium check the pH of that medium than after further procced if not then check the solubility in organic solvents on basis of solubility and pH of the Mobile phase. Both Mobile phase selection and stationary phase are selected.

what is the origin to prepare standard operating procedure

2314

---

why require the ph, buffer during hplc mobile phase?

850

---

what is impurity profile. how to interpret this impurity profile to a drug product or drug substance.

2624

---

how you start RS method development when for new product?

712

---

What is the difference between chromatographic purity and related substances?

1358

---

What is the difference between spectro meter and spectro photo meter?

11479

---

how a particular wavelength can be different for a particular compund while analysing by uv and by HPLC.

2282

---

what is difference in ods I ods II is this is realy from sorbent / packing characteristics or from other means

1961

---

What is the diffrence in japan mkt requirement in analytical method validation over US?

711

---

how you determine moist.of NaOH sol or NaOH flacks

2209

---

How to do regeneration of Metacarb Pb plus column?

2573

---

calibrtion procedue of LC-MS

2702

---

please explian me about area normalisation method,diluted standard method,impurity vs impurity and which one has to be selected in method development

1620

---

What is rs test why we are performing rs test?

1850

---

What is the purpose of octyl silane columns?

4284

---