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Why we use basket in place of bowl in
dissolution apparatus
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Answer Posted / nimittank
Basket is mainly used when the Dissolution Medium must have to get changed during the testing ( in continuation ). During the dissolution Analysis of Enteric Coated units first we use to check dissolution of the API in to the 0.1 N HCl medium in order to check any release of drug in Acid medium or not for 2 hours ( equal to gastric Emptying time ) than we changed medium to 6.8 pH phosphate buffer equal to Intestinal fluid to carry out complete dissolution of the dosage form.
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