What is limit of disintegration for Enteric coated tablets?
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Answer Posted / sharmin akther
For tablets covered with a gastro-resistant coating, Use 0.1 M hydrochloric acid as the liquid. Operate the apparatus for 2 h, without the discs and examine the state of the tablets. The time of resistance to the acid medium varies according to the formulation of the tablets to be examined. It is typically 2 h to 3 h but even with authorised deviations is not less than 1 h. Replace the acid by phosphate buffer solution pH 6.8 R and add a disc to each tube. Operate the apparatus for 60 min and examine the state of the tablets.
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