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What is limit of disintegration for Enteric coated tablets?
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two hours if the disintegrating medium use is phosphate
buffer and tablets do not disintegrate if the medium is acidic
| Is This Answer Correct ? | 6 Yes | 3 No |
Answer / lokesh
in acidic medium tablet should not release the drud for 2 hrs.in phosphate buffer it should release drug in 1 hr...
| Is This Answer Correct ? | 4 Yes | 2 No |
Answer / sharmin akther
For tablets covered with a gastro-resistant coating, Use 0.1 M hydrochloric acid as the liquid. Operate the apparatus for 2 h, without the discs and examine the state of the tablets. The time of resistance to the acid medium varies according to the formulation of the tablets to be examined. It is typically 2 h to 3 h but even with authorised deviations is not less than 1 h. Replace the acid by phosphate buffer solution pH 6.8 R and add a disc to each tube. Operate the apparatus for 60 min and examine the state of the tablets.
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / nikita
For enteric coated tablets, not disintegrate in acidic medium for 2 hours, after replacing phosphate buffer, it disintegrate in half hour
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Answer / saikiran polsani
in acid medium 1hr,Should not release the drug,after that 2hrs in 6.8 phosphate buffer.
| Is This Answer Correct ? | 0 Yes | 1 No |
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