Answer Posted / sivannarayana

1.Solubility
2.Find out the UV scan For wave length
3.optimaize Buffer & pH Value Optimaize
4.Optimaize Column Temparature & optimaize sample cooler Temparature.
5.optimaize the GP For better Resolution

If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

856

---

in OSD forms require to use gas chromatography?

834

---

I have compare C2H2-air and C2H2-N2O flame AAS on determination calcium. Both use same range of std to plot calibration curve. (2-6ppm) When i measure the sample with phosphate, KCl and LaCl, C2H2-N2O flame give false positive result, around 0.5ppm. When i measure the sample with phosphste, KCl and EDTA. C2H2-N2O flame also give 0.5ppm false positive. But both above mentioned sample would not give false positive when measured by C2H2-air flame. What is the reason?

3540

---

In performance Check of GC Why Hexadecane Peak is Considered 

3044

---

What is delay volume?

1394

---

If we do accuracy at same concentration at which linearity planned,what is the need to do linearity separately?

2302

---

what is mean by ambient temperature?

916

---

cefoperozone and sulbactam inj. hplc test method

2691

---

in stress study if your api not soluble in hcl naoh h2o2 then what require to do?

837

---

how you start the solubility study?

826

---

in each media we require to use SLS? how to proceed?

787

---

WHY given much noise PDA dector then VWD Dector

2100

---

if your product is soluble in 0.1n hcl and water then which you choose as media from these 2 media?

679

---

How to set analytical specification for combination products?

818

---

How to start the dissolution development for unknown tab?

1679

---