Answer Posted / k.lavanya

HPLC is high performance liquid chromatography, whereas UPLC is ultra high performance liquid chromatography

In essence, UPLC is just a special variant of HPLC


The pump pressure, which is 40Mpa (400 atmospheres) in HPLC, can go up to 100MPa in UPLC. UPLC also allows for much smaller particle size, normally less than 2um whereas it is normally 5um in HPLC.

why we use glass fiber filters use in some situation?

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why require to add enzymes in capsules dissolution only? is it require to tablet also?

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Please give idea about method development for cleaning method and how maco level establish

278

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how we can identify the impurity is coming below loq at transfering site?

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how require to interprit the method precision data of hptlc?

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why require to do water content for drug product?

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how pda detector works over uv?

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Why dissolution test is not performed in all of the products

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Why only Copper standard is used to calibrate Atomic Absorption spectrophotometer?

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what is the procedure for cleaning of lenses of hatr accesory of ftir instrument?

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in monograph 7 imp are there but in vendor showing 5 imp do not req to include 2 imp for that what will be justification?

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what is lod and loq ?,why use k2cr2o7 , kcl h2so4 in uv calibration ?,why use benzophenone & caffene acetone in hplc calibration ?,what is leading peak in hplc ?why we do the calibration of limit of stry light in hplc & uv ?

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If vendor having more imp than monograph then how to proceed? and how to set spec?

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inhouse product is in capsule form in combination and RLD is in tablet form then can we proceed for multimedia CDP? in inhouse capsule product disso is paddle with sinker in release media is there then RLD product in tablet form then with same as paddle with sinker we can proceed n.a.?

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WHICH STANDARD WE USE IN SILICA ANALYSIS IN SILICA-GEL METHOD FOR SOLID SAMPLE

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