Why we more noise in PDA detector compared to UV detector?
Answer Posted / anil
There is no Integration function in the conventional UV-Vis spectrophotometer which
accumulates the signal. For example, the total required time will be 1000 sec. for 1000 data
points and it takes 1 sec. to measure one datum. In this case, all 1000 data have the same signal
to noise ratio (S/N).
But in a PDA instrument which has a 1000 photodiode array, 1000 data points can be
measured in 1 sec. and it would take 1/1000 sec. to achieve the same result obtainable in 1 sec.
in a conventional instrument. Therefore, when the same sample is measured for 1000 sec in a
PDA instrument, the signal is accumulated and is 1000 times greater than when measuring for 1
sec. The noise will be 10001/2
. This means that the S/N ratio is improved by 10001/2
.
This resulting benefit of fast data acquisition is termed Felgett’s S/N Advantage or
Multichannel Advantage
Is This Answer Correct ? | 10 Yes | 1 No |
Post New Answer View All Answers
Explain the relations between number of carbon atoms in alkanes and retention time ?
WHAT IS THE USE OF STARTER ?????????
How do we quantify crystaline and amarpous forms by using (NMR, XRD)spectroscopic techniques? Which any others instruments are useful for this quantification? explain
how require to set assay concentration for standard and sample?
How will u perform degradation study in detectors other thann PDA in HPLC Methodology
What is the main difference between ODS1 and ODS2 Hplc column.
What is similarity factor?
In the HPLC Calibration done wavelength accuracy done between 200nm-280nm .but not done remaining 300-400nm not done ?
What is similarity factor and its use in api strength?
if you given one product then which tests you will perform?
why salisylic acid not using now days for disdolution calibration?
What are usp limits for theoritical plats,resoution,tailing factor,peak to valley ratio
Why perchloric acid used for potentiometric titration
WHAT IS THE CRITERIA FOR SELECTION OF TIME OF DISSOLUTION AND THE MEDIUM OF DISSOLUTION?
How to calculation of residual solvent methanol (3000 ppm) standard solution, and how many quantity used of test sample