Dear Sir,
This is Thirunavukkarasu am working in Ordain Health Care
AR&D, Am Having one problem While doing method development
my question Metadoxine and Pyridoxine same chemical nature
and structural activity i tried lot of methods but Analyte
eluted same Retantion time i cant separate both peaks.
solubility, pH both are same only only difference melting
point metadoxine 210 C Pyridoxine 102 C please do the help
needful for me
Answer Posted / guest
its better to used ELSD detetor for the analysis
| Is This Answer Correct ? | 0 Yes | 1 No |
Post New Answer View All Answers
what is the origin to prepare standard operating procedure
If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?
what is mean by covalidation
How will u perform degradation study in detectors other thann PDA in HPLC Methodology
how to qualify the impurity?
is it nessesary to do solution stability for 7 days?
pharma industries oriented
How you develop a method in HPLC?
1.What is the difference between method validation and method verification 2.Which guidelines proposed to method transfer
What is the main difference between ODS1 and ODS2 Hplc column.
How do we fix the sample concentaryion in hplc method development?
What is the Formula for coreletion coefficient in plhplc calibration
what is %labelled amount in content uniformity of dosage unit and its calculation?
What is the accrptance criteria in RSD for RS method precision on basis of impurity percentages?
In HPLC calibration, caffeine is used as primary standard for wave length calibration due to caffeine is having dual maxima at 273 & 205 nm and one minima at 245 nm. Any body can give reference of these details from any pharmacopeia (with chapter no.) or any other authentic guideline?