Answer Posted / archana

PVT Test in dissolution test means performance verification test which is also known as apparatus suitability test

Frequency of this test is once in six months.

This can be done by using prednisone USP Tablet 10 mg /tablet
for disintegrating type of tablets.

Current lot for this tablet is O0C056.

For Type 1 Apparatus
Dissolution medium :900 ml water
Temp :37°C
RPM :50
%dissolved :53-77%(O0C056)
Time :30mins
For Type 2 Apparatus
Dissolution medium :900ml water
Temp :37°C
RPM :50
%dissolved :27-48%(O0C056)
Time :30mins
Readings r taken at 242 nm
Std concentration 20 mg /ml of prednisone USP

Salicylic Acid Tablets are used for non disintegrating type of tablets
Current lot is Q0D200

For Type 1 Apparatus
Dissolution medium :900 ml of phosphate buffer of pH 7.4+/-.005
Temp :37°C
RPM :50
%dissolved :23-29%(Q0D200)
Time :30mins
For Type 1 Apparatus
Dissolution medium :900 ml of phosphate buffer of pH 7.4+/-.005
Temp :37°C
RPM :50
%dissolved :17-26%(Q0D200)
Time :30mins
Readings r taken at 296 nm
Std concentration 75 mg /ml of Salicylic acid USP

in sampling of raw material which side is pasted sampled labels

1886

---

if you have given a blank water how you analyse by general analytical techniques?

2083

---

mahagenco syllabus for the post of chemist

6512

---

how require to interprit the method precision data of hptlc?

869

---

Qc interview questions

1793

---

if your product is soluble in 0.1n hcl and water then which you choose as media from these 2 media?

735

---

what is turbidimetric titration?Give 2 examples.

2732

---

Identify problem faced when mass spectroscopy is used with HPLC system ?

1926

---

How can we calculate "confidence interval" in analytical method validation? Pl. explain with example.

4368

---

calibrtion procedue of LC-MS

2758

---

in api coa contains only process impurities and in product coa contains degradation impurities?

733

---

why octanol used to determine the partition coefficient ?

2495

---

if you get peak in blank then what require to do?

1018

---

how you confirm the assay method?

826

---

My question about gas chromatography sulfur chemiluminsecence detector. I test unknown sample gas by GC-SCD (calibrated ) and the result of *H2S is 279 PPM , *but when I test the same sample with the GC-TCD (calibrated ) the value of *H2S is 2500 PPM . I'd like to inform you that both GCs are calibrated and have very good operation conditions with stable parameters . the question is if the sample gas with higher H2S over detection limits of SCD detector (1000 ppm). why the result it 279 ppm Best regards

1651

---