Answer Posted / pankaj shrivastava

There are some factors and parameters by which we can
decrease the run time as....
1. by increasing flow Rate
2. by increasing lightly Column oven temperature.
3. by increasing mobile phase strength.
3. by using short length column.

if your impurity coeluting with each other in that situation how require to set specification? is it acceptable?

900

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what is third integration

1929

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If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

796

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2260

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Which products will produce when acetic anhydride reacts with Ter-butanol, Sec-butanol, Iso butanol, Dimethylamine etc.

2829

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in api coa contains only process impurities and in product coa contains degradation impurities?

654

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If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?

931

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Explain the relations between number of carbon atoms in alkanes and retention time ?

2072

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what is the importance of peak purity in HPLC and how we can calculate through manul(not software)?

4420

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in DMF having extra impurities and in api COA also having extra imp than USP or BP product then how require to proceed?

776

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WHY pKa value is more important than pH value of the mobile phase in HPLC?

1712

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how to calibrate hplc & gc

4461

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give clarity of linearity and range in method validation

2379

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In rs method development when we are going area normalization method to dilute standard method?

1474

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what are the standard methods for HPLC?

2734

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