Interested to Buy Any Domain ? << Click Here >> for more details...
In the method validation proceedure,lod & loq calculation we use the formulae for LOD=3.3*SD/slope and for LOQ=10*SD/slope,why we use 3.3 & 10 in the formulae?
- 1 Answers
- 11007 Views
- I also Faced
- E-Mail Answers
Answer Posted / veeru01
LOD :- LOD is measured 10 times independent sample of Blank
and Student-t test of 10 times, Degree of freedom 9 (n-1)at
99% confidence label is 3.25 as per Student chart. Also
Ratio of S/N =3:1
LOQ:- LOD is regarded as the lower limit for precise
quantitative Measurement . LOQ defined as concentration
which would a produce a signal 10-12 time. At this point
standard deviation is small enough (Approximately 10-15%) so
that quantified value can be deemed reliable. Also Ratio
S/N= 10:1
| Is This Answer Correct ? | 7 Yes | 3 No |
Post New Answer View All Answers
please explian me about area normalisation method,diluted standard method,impurity vs impurity and which one has to be selected in method development
WHAT IS THE USE OF STARTER ?????????
how a particular wavelength can be different for a particular compund while analysing by uv and by HPLC.
what is the difference between potentiometric titration and karl fischer titration?
why we use Dichlorobenzene.nitrobezine.t-butyldi sulhate.for calibration of gc Head space
what you do when compound having dwel wavelength?
How do we fix the sample concentaryion in hplc method development. What is the basis?
what is partion and column chromatography
IS THERE ANY EQUIPMENT TO CHECK AND CALCULATE THE POLARITY OF A LIQUID?
what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?
How doing qbd practically?
In GC calibration,what is the procedure to calibrate the TCD (thermal counductivity detector)suggest ?
How we can identify process related and degradation impurity in single method with short period?
how you confirm the assay method?
how require to select dissolution media? what is discrimination?
