If compound Pka is 5 then which buffer you will select ?
Answer Posted / sandip ankolia
u can not say that if Pka is 5 so use buffer near about pka
5 but depends upon the nature of compound , drift and noise.
genrally u can selet pH +/- 1.5 unit of the Pka value of
the compound.
Most important thing is that its not react with buffer,
| Is This Answer Correct ? | 5 Yes | 0 No |
Post New Answer View All Answers
is it necessary to do HPLC calibration at wavelength 315nm if we are doing analysis at this wavelangth
what is the acceptance criteria for enteric coated tablets in 0.1n hcl validation in each parameter?
In HPLC (Waters) software Empower1,2 &3 what is the updation for each version
Is it nessesary all multimedia dissolution require descriminatory?
In which situation we require to analytical method validation of excipient?
What is aggregate and fragments in SEC?
how to set sample and standard concentration in RS method?
What is importance of pH in the Heavy metal test and How it effect on the test results?
How can we calculate offset value pH measurment
Why we check moisture,ash & AIA in product
If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?
if you have given one product then how you determine the impurity in that?
In IR spectra, generally a molecule vibrates without apply emr or ir light?
Why dissolution test is not performed in all of the products
in api coa contains only process impurities and in product coa contains degradation impurities?