Answer Posted / sures babu

Capillary columns 100 micron or less in internal diameter
so the sample vlume what we are injected is to high for
column thus split help to dived the volume and pass throuh
less amount and remaning sample gone as a wasre.

How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.

2359

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why salisylic acid not using now days for disdolution calibration?

836

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why holium oxide prepared in 10% HCLO4 SOLUTION

1492

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on saturation solubility study data how we can find out the bcs class of drug?

956

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What are modes of quantification in related substances

2212

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what are the standard methods for HPLC?

2830

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If inhouse hplc related substance method is completly diffrent from Usp for finished proďuct with diffrent impurities then how require to prove method equivalecy?

816

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In which situation we require to analytical method validation of excipient?

841

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What is the difference between spectro meter and spectro photo meter?

11614

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how to get accurate result for Residue on evaporation in purified water

1697

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How to determine water content of bis tetrazole amine mono ammonium salt

3529

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what is the structure of DOWEX-50

5559

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If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

903

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some product having water content method with pyridine and ethylene glycol mixture instead of methanol? how they are selecting and methanol is not suitable solvent how ?

2704

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if rsd failed then what require to do?

877

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