Answer Posted / ramana

Parameters involved during initial stage of Analytical
Method development:

1. Solubility
2. Pka Value
3. Selection of Buffers
4. pH of buffer/mobile phase
5. Composition of Mobile Phase
6. Selection of Column
7. Optimization of Analyte signal
8. Objectives of Seperation
8.1 Analysis time
8.2 Resolution
8.3 k factor (Capacity factor)
8.4 Peak height
8.5 Asyymetry
8.6 Theoritical Plates
9. Flow rate

Is it nessesary all multimedia dissolution require descriminatory?

797

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what is mean by dissolution biowaiver study?

933

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mode of absorption in alimentary canal?

2392

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how require to fix the linearity and accuracy cincentration range?

1671

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Which parameter require to do for analytical method equivalency?

782

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In the HPLC Calibration done wavelength accuracy done between 200nm-280nm .but not done remaining 300-400nm not done ?

926

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what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?

3692

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How would you decide dissolution medium for NCE compound of class I drug

2258

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what is the importance of peak purity in HPLC and how we can calculate through manul(not software)?

4489

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What is the principle of Thermal conductivity detector and FID?

2733

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How do we fix the sample concentaryion in hplc method development. What is the basis?

1209

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Related substance method equivalency on control sample or spiked sample?

771

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some product having water content method with pyridine and ethylene glycol mixture instead of methanol? how they are selecting and methanol is not suitable solvent how ?

2655

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What is gelatinization?

1618

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Loss of linearity in tkn analysis, possible reasons?

1319

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