Answer / kumar saurabh

Only if you're performing a multistep update and want the update to be treated as an atomic operation. Here's an example:
Application.Lock ();
Application["ItemsSold"] = (int) Application["ItemsSold"] + 1;
Application["ItemsLeft"] = (int) Application["ItemsLeft"] - 1;
Application.UnLock ();
By locking application state before updating it and unlocking it afterwards, you ensure that another request being processed on another thread doesn't read application state at exactly the wrong time and see an inconsistent view of it.

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