Why do proteins that recognize specific DNA sequences
usually bind in the major groove of DNA?
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Answer / gurudut
The major groove is wider and deeper and provides more
variety in terms of interaction between amino acid side
chains and DNA bases.
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Answer / ramanuj
dsDNA shows major and minor grooves all along its spiral
structure. Major grooves are more accessible to different
outside molecules that interacts with DNA. Or one can say
major grooves are more open for the interaction. That's the
reason why proteins usually bind to the major grooves of
DNA.
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