Interested to Buy Any Domain ? << Click Here >> for more details...
Answer Posted / vinod kumar uppalli
The Si-OH functional groups of silica bed tend to ionize at higher pH and convert into negatively charged Si-O functional group and this interacts with acidic moieties and leads to tailing of peak due to secondary interactions. To overcome this most of the columns are end capped (Si-OH GROUP IS SHIELDED) to avoid secondary interactions.
| Is This Answer Correct ? | 1 Yes | 0 No |
Post New Answer View All Answers
How to set analytical specification for combination products?
Why only Copper standard is used to calibrate Atomic Absorption spectrophotometer?
in monograph 7 imp are there but in vendor showing 5 imp do not req to include 2 imp for that what will be justification?
What is Band broading effect explain
WHAT IS THE PARAMETER FOR THE SELECTION OF MOBILE PHASE IN HPLC?
What is the difference between Discriminating media and DPDM(Dissolution Profile with Different Media)
Tell me about analytical method validation in QC
can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?
what is the difference between potentiometric titration and karl fischer titration?
we are performed SOR for a particular product the limit is -6 to -10.We face particular bathes it is not meeting the specification.we performed diffrent instrument diffrent analyst we are getting diffrent diffrent results.solvent is dimethyl sulfoxide what could be the reasion
how to calculate elemental impurities?
can i use hplc detector to uplc and why?
what is the principle of UV Vis spectroscopy, AAS, ICP OES,ICPAES, ICP-MS and FTIR
how decide the clining method and cleaning method validation require for this perticular products?
what is partion and column chromatography
