Interested to Buy Any Domain ? << Click Here >> for more details...
Answer Posted / ravi kumar thota
Silica is an amorphous polymer of silicon and oxygen. This polymer terminates at the surface of the particle as –Si-OH groups, commonly called “silanols.” These silanol groups serve as attachment sites for the bonded phase. A silane reagent, such as Cl(CH3)2SiC18H37 is reacted with the silanol to form a silyl ether (–Si-O-Si-). The bulk of the C18 group prevents bonding to all of the exposed silanols. This results in a surface that looks much like that on the left side of Figure 1, where there is a fairly high population of unbounded silanols, often termed “residual silanols.” The residual silanols are somewhat acidic and can be overly reactive with sample components, especially basic analytes, so it is preferable to reduce the population of residual silanols.
| Is This Answer Correct ? | 0 Yes | 0 No |
Post New Answer View All Answers
what is third integration
how you fix the limits of impurities?
Why use only methanol,used determinationof moisture content not use other solvents
In Assy by potentio metry titration method how select MET U ,DET U, SET U,
What is the difference between Discriminating media and DPDM(Dissolution Profile with Different Media)
How would you decide dissolution medium for NCE compound of class I drug
pharma industries oriented
Which parameter require to do for analytical method equivalency?
how to selecet an exact coloumn for an new molecule development by hplc how to select exact salt as buffer for new molecule development by hplc what is the the process to select the mode of saparation of compoundes by hplc what is the use of ph of buffer what is use of buffer,ph,organic phase,ans methods how the molecules get saparated in coloumn,
How to calculate coreletion coefficient
How to set analytical specification for combination products?
EXPLAIN THE CALCULATION PART OF AN KF TITRATOR CALIBRATION WITH SUITABLE EXAMPLE
How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.
2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.
if tech transfer fails whay require to do?
