Answer Posted / ram

The common procedure for fixing the LOQ is assuming u r specification as 100 % and we have to achieve LOQ below 50% of specification, here impurities are may be known or unknown.
for exm. known imp limit is 1.0 % then u should try to get LOQ below 0.5%, however if u try for very low level then it is well n good.

All unknown impurities will have spe of 0.1% limit and we have to do validation of unknown with active .

How do we fix the sample concentaryion in hplc method development. What is the basis?

1245

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why sre you used Potassium hydrogen phthalate in standarisation of 1N NaOH and 0.1 N Perchloric Acid?

9882

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How much is the standard area for glc analysis

2328

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For titration in anhydrous media with perchloric acide, if lack of titrator, Which indicator is been used for replacement. How calculate pH of test solution to choose suitable indicator?

2356

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what is mean by dissolution biowaiver study?

990

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What is mean by PDR?

1023

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Why we use potassium dichromate in uv calibration Exact reason behind it??

1320

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What is the calibration of uv process and preparation

2044

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Ratio of Water and Acetonitrile(diluent) is not recommended to use in cleaning method validation,why?

3016

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why require to add enzymes in capsules dissolution only? is it require to tablet also?

723

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why are measure gas flow " ml " in Gas chromatography

1697

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please explain about aluminium hydroxide assay

1176

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If combination product how require to identify which imp is of which api?

861

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In performance Check of GC Why Hexadecane Peak is Considered 

3102

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if peak get problamatic then what require to do?

856

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