What is peak purity and response factor in chromatographic analysis? Why we required to find out response factor?
- 2 Answers
- 6528 Views
- I also Faced
- E-Mail Answers
Answer Posted / venkata naveen talluri
Peak purity=It indicates whether the peak is single or co-eluting with any other analyte. If peak purity is passing it indicates it is single peak. based on the Noise and co-eluting peaks the peak purity depends.
Response factor/Relative response factor/RRF=the response of an impurity withrespect to main peak at a particular nanometer.All impurities will not have equal responses with API. RRF needs to be established because impurities are very costly and each time of analysis it is difficult to be used. So establish an RRF and use the RRF for calculation in repoting the impurity value
| Is This Answer Correct ? | 11 Yes | 0 No |
Post New Answer View All Answers
why should we perform dissolution PVT calibration only by UV spectrometer, not by HPLC ?
how decide the clining method and cleaning method validation require for this perticular products?
My question about gas chromatography sulfur chemiluminsecence detector. I test unknown sample gas by GC-SCD (calibrated ) and the result of *H2S is 279 PPM , *but when I test the same sample with the GC-TCD (calibrated ) the value of *H2S is 2500 PPM . I'd like to inform you that both GCs are calibrated and have very good operation conditions with stable parameters . the question is if the sample gas with higher H2S over detection limits of SCD detector (1000 ppm). why the result it 279 ppm Best regards
what is mean by dissolution hydrodynamics?
how can give the expiry period and restadardisation of volumetric solution
mode of absorption in alimentary canal?
In performance Check of GC Why Hexadecane Peak is ConsideredÂ
what is the importance of peak purity in HPLC and how we can calculate through manul(not software)?
why require to add enzymes in capsules dissolution only? is it require to tablet also?
sop of a uv visible spectrophotometer double beam elico model
How can we calculate offset value pH measurment
What is aggregate and fragments in SEC?
how require to fix the linearity and accuracy cincentration range?
How to choose the which salt is suitable for mobilephase
how many types of balance calibration test?
