Why linearity of detector performed in HPLC calibration
Answer Posted / alexander
Checking the detector response with know concentration of
of standard ,to ensure that your detector response is
directly related to your concentration.i.e response should
be linearly increase with concentration
And
Also check the injector performance
Is This Answer Correct ? | 3 Yes | 2 No |
Post New Answer View All Answers
analytical method validation require to with respect to release specification or shelf life specification?
why sre you used Potassium hydrogen phthalate in standarisation of 1N NaOH and 0.1 N Perchloric Acid?
in monograph 7 imp are there but in vendor showing 5 imp do not req to include 2 imp for that what will be justification?
What is the diffrence in japan mkt requirement in analytical method validation over US?
Why dissolution test is not performed in all of the products
Why we select scan range from higer wavelength to lower wavelength in uv visible spectroscopy and ftir spectroscopy ? .
How much is the standard area for glc analysis
what is difference in ods I ods II is this is realy from sorbent / packing characteristics or from other means
Why sodium hydroxide used for maintain pH of phosphate buffer
In GC calibration,what is the procedure to calibrate the TCD (thermal counductivity detector)suggest ?
in each media we require to use SLS? how to proceed?
if identification threshold crosses the limits then what next step?
in dissolution if one bowl got 70 percent 2nd bowl got 80 percent and 3rd bowl got 90 percent then how proceed?
If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately
why does used dry caffien in HPLC calibration?